Detalhe da pesquisa
1.
Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation.
Cell
; 183(2): 490-502.e18, 2020 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33002410
2.
Phase separation underlies signaling activation of oncogenic NTRK fusions.
Proc Natl Acad Sci U S A
; 120(42): e2219589120, 2023 10 17.
Artigo
Inglês
| MEDLINE | ID: mdl-37812694
3.
Targeting androgen receptor phase separation to overcome antiandrogen resistance.
Nat Chem Biol
; 18(12): 1341-1350, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36229685
4.
A novel partially open state of SHP2 points to a "multiple gear" regulation mechanism.
J Biol Chem
; 296: 100538, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33722610
5.
Phase separation ability and phosphatase activity of the SHP1-R360E mutant.
Biochem Biophys Res Commun
; 600: 150-155, 2022 04 16.
Artigo
Inglês
| MEDLINE | ID: mdl-35219918
6.
Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.
Mol Cell
; 53(2): 247-61, 2014 Jan 23.
Artigo
Inglês
| MEDLINE | ID: mdl-24389101
7.
Inhibition of cIAP1 as a strategy for targeting c-MYC-driven oncogenic activity.
Proc Natl Acad Sci U S A
; 115(40): E9317-E9324, 2018 10 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30181285
8.
Radical-induced metal-free alkynylation of aldehydes by direct C-H activation.
Chemistry
; 21(24): 8745-9, 2015 Jun 08.
Artigo
Inglês
| MEDLINE | ID: mdl-25925698
9.
Fluorination of 2-substituted benzo[b]furans with Selectfluor™.
Org Biomol Chem
; 13(11): 3190-3, 2015 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-25656093
10.
Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach.
J Med Chem
; 67(2): 1079-1092, 2024 Jan 25.
Artigo
Inglês
| MEDLINE | ID: mdl-38166388
11.
RNA-Guided DNA Transposition in Corynebacterium glutamicum and Bacillus subtilis.
ACS Synth Biol
; 12(7): 2198-2202, 2023 07 21.
Artigo
Inglês
| MEDLINE | ID: mdl-37348112
12.
Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy.
JAMA Neurol
; 80(6): 578-587, 2023 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37126322
13.
Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation.
J Biol Chem
; 286(44): 38725-38737, 2011 Nov 04.
Artigo
Inglês
| MEDLINE | ID: mdl-21880715
14.
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.
Proc Natl Acad Sci U S A
; 105(18): 6584-9, 2008 May 06.
Artigo
Inglês
| MEDLINE | ID: mdl-18451027
15.
Screening inhibitors for blocking UHRF1-methylated DNA interaction with capillary electrophoresis.
J Chromatogr A
; 1636: 461790, 2021 Jan 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33340746
16.
Rational design of a potent macrocyclic peptide inhibitor targeting the PD-1/PD-L1 protein-protein interaction.
RSC Adv
; 11(38): 23270-23279, 2021 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35479790
17.
Modeling tumor development and metastasis using paired organoids derived from patients with colorectal cancer liver metastases.
J Hematol Oncol
; 13(1): 119, 2020 09 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32883331
18.
GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats.
Sci Rep
; 10(1): 5265, 2020 03 24.
Artigo
Inglês
| MEDLINE | ID: mdl-32210319
19.
Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration.
Eur J Med Chem
; 183: 111694, 2019 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31561044
20.
Novel Triapine Derivative Induces Copper-Dependent Cell Death in Hematopoietic Cancers.
J Med Chem
; 62(6): 3107-3121, 2019 03 28.
Artigo
Inglês
| MEDLINE | ID: mdl-30835473